Article

Gene-based burden scores identify rare variant associations for 28 blood biomarkers

2023-02-10

Abstract excerpt

<h4>Background: </h4> A relevant part of the genetic architecture of complex traits is still unknown; despite the discovery of many disease-associated common variants. Polygenic risk score (PRS) models are based on theevaluation of the additive effects attributable to common variants and have been successfully implemented to assess the genetic susceptibility for many phenotypes. In contrast, burden tests are often...

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Literature Corpus work: 4c3bff58-bac4-56c4-bf16-9929f9e54b4f
DOI: 10.21203/rs.3.rs-2271894/v1

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