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Article

Cardiac ion channel safety profiling on the IonWorks Quattro automated patch clamp system.

Assay and drug development technologies - 1 Dec 2010

Cao Xueying, Lee Yan Tony, Holmqvist Mats, Lin Yingxin, Ni Yucheng, Mikhailov Dmitri, Zhang Haiyan, Hogan Christopher, Zhou Liping, Lu Qiang, Digan Mary Ellen, Urban Laszlo, Erdemli Gül

Abstract excerpt

The normal electrophysiologic behavior of the heart is determined by the integrated activity of specific cardiac ionic currents. Mutations in genes encoding the molecular components of individual cardiac ion currents have been shown to result in multiple cardiac arrhythmia syndromes. Presently, 12 genes associated with inherited long QT syndrome (LQTS) have been identified, and the most common mutations are in...

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Identifiers

PMID: 21133679
DOI: 10.1089/adt.2010.0333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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