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Article

Glioblastoma induces CAF-like astrocyte activation via the AKT/mTOR–SERPINH1/COL5A1 axis

12 Jun 2025

Abstract excerpt

Glioblastoma multiforme (GBM), the most aggressive form of glioma, remains the most malignant tumor of the central nervous system. Despite a range of therapeutic strategies, the prognosis for GBM patients remains poor, underscoring the urgent need for novel treatments to inhibit GBM progression. The tumor microenvironment (TME) plays a critical role in tumor development, with cancer-associated fibroblasts (CAFs)...

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PMID: 40530702
DOI: 10.17305/bb.2025.11898

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