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Roles of the Y chromosome genes in human cancers

1 Jan 2015

Abstract excerpt

Male and female differ genetically by their respective sex chromosome composition, that is, XY as male and XX as female. Although both X and Y chromosomes evolved from the same ancestor pair of autosomes, the Y chromosome harbors male-specific genes, which play pivotal roles in male sex determination, germ cell differentiation, and masculinization of various tissues. Deletions or translocation of the...

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PMID: 25814157
DOI: 10.4103/1008-682x.150842

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