Article

RAS-activated PI3K/AKT signaling sustains cellular senescence in experimental models of psoriasis via P53/P21 axis

2023-08-08

Abstract excerpt

<title>Abstract</title> <p>Psoriasis is a chronic immune-mediated skin disease in which upper epidermal keratinocytes exhibit a senescent-like phenotype. In psoriatic skin, a variety of inflammatory cytokines can activate intracellular pathways including phosphatidylinositol 3-kinase (PI3K)/AKT signaling and RAS effectors. AKT and RAS participate to cellular senescence, but currently their role in senescence resp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 12df2758-c04c-5ab7-ad30-9ad336ee7937
DOI: 10.21203/rs.3.rs-3209194/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RAS-activated PI3K/AKT signaling sustains cellular senescence in experimental models of psoriasis via P53/P21 axisDOI 10.21203/rs.3.rs-3209194/v1Read

Recent Updates on the Involvement of PI3K/AKT/mTOR Molecular Cascade in the Pathogenesis of Hyperproliferative Skin DisordersSemantic proximity Read

The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and SenescenceSemantic proximity Read

MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulationSemantic proximity Read

Photomodulation Alleviates the Senescence of Adipose-Derived Stem Cells Aging in VitroSemantic proximity Read

S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasisSemantic proximity Read

Akt-induced cellular senescence: implication for human disease.Semantic proximity Read

AKT1 is Required for a Complete Palbociclib-induced Senescence Phenotype in BRAF-V600E-Driven Human MelanomaSemantic proximity Read

Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.Semantic proximity Read

Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.Semantic proximity Read

18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in miceSemantic proximity Read

Ras, PI3K/Akt and senescenceSemantic proximity Read

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancySemantic proximity Read