Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low-Dose Pesticide Mixture Induces Senescence in Normal Mesenchymal Stem Cells (MSC) and Promotes Tumorigenic Phenotype in Premalignant MSC.

Stem cells (Dayton, Ohio) - 1 Mar 2017

Hochane Mazene, Trichet Valerie, Pecqueur Claire, Avril Pierre, Oliver Lisa, Denis Jerome, Brion Regis, Amiaud Jerome, Pineau Alain, Naveilhan Philippe, Heymann Dominique, Vallette François M, Olivier Christophe

Abstract excerpt

Humans are chronically exposed to multiple environmental pollutants such as pesticides with no significant evidence about the safety of such poly-exposures. We exposed mesenchymal stem cells (MSC) to very low doses of mixture of seven pesticides frequently detected in food samples for 21 days in vitro. We observed a permanent phenotype modification with a specific induction of an oxidative stress-related...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipogenesis
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Respiration

Share to Cellular Senescence

Share to Endothelial Cells

Share to Mesenchymal Stem Cells

Share to Pesticides

Share to Precancerous Conditions

Source

Identifiers

PMID: 27860054
DOI: 10.1002/stem.2539

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low-Dose Pesticide Mixture Induces Senescence in Normal Mesenchymal Stem Cells (MSC) and Promotes Tumorigenic Phenotype in Premalignant MSC.PMID 27860054Read ↗

Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process.Semantic proximity Read ↗

Chronic Exposure to Nanoplastics Alters Stem Cell Type-Specific Mechanisms, Promoting Cancer DevelopmentSemantic proximity Read ↗

Mesenchymal Stromal Cells showed an alteration of differentiation potential under Environmental Micro and Nanoplastics ExposureSemantic proximity Read ↗

Effects of the Endocrine-Disrupting Chemical DDT on Self-Renewal and Differentiation of Human Mesenchymal Stem CellsSemantic proximity Read ↗

Toxicity impacts on human adipose MSCs acutely exposed to Aroclor and non-Aroclor mixtures of PCBsSemantic proximity Read ↗

Aged polystyrene microplastics exacerbate alopecia associated with tight junction injuries and apoptosis via oxidative stress pathway in skinSemantic proximity Read ↗

Formaldehyde-induced toxicity causes senescence and apoptosis in BMSCs via PI3K/P53 signaling pathwaysSemantic proximity Read ↗

Phenotypic and lipidomic alterations in lung cells induced by organophosphate flame retardants.Semantic proximity Read ↗

Nanoplastics and Arsenic Co-Exposures Exacerbate Oncogenic Biomarkers Under an in Vitro Long-Term Exposure ScenarioSemantic proximity Read ↗

Systemic safety and immunophenotypic profiles of human adipose-derived mesenchymal stem cell exosomes: A comprehensive toxicological assessmentSemantic proximity Read ↗

Disruptive chemicals, senescence and immortalitySemantic proximity Read ↗

Asbestos exposure induces malignant-like phenotypes via minority MOMP and displays characteristics of drug-tolerant persister cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.