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Endogenous retroviruses are dysregulated in ALS

28 May 2024

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease with no cure. Human endogenous retroviruses (HERVs) have been implicated in its pathogenesis but their relevance to ALS is not fully understood. We examined bulk RNA-seq data from almost 2,000 ALS and unaffected control samples derived from the cortex and spinal cord. Using different methods of feature selection, including...

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PMID: 38989463
DOI: 10.1016/j.isci.2024.110147

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