Article

Primary Nasal Epithelial Cells As a Type-II Alveolar Surrogate Cell Culture Model for ABCA-3 Deficiency

2021-09-08

Abstract excerpt

ATP Binding Cassette Subfamily A Member 3 (ABCA-3) is a lipid transporter protein highly expressed in type-II alveolar (AT-II) cells. Mutations in ABCA3 can result in severe respiratory disease in infants and children. To study ABCA-3 deficiency in vitro , primary AT-II cells would be the cell culture of choice although sample accessibility is limited. Our aim was to investigate the suitability of primary nasal ep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b882569-b0c3-51d1-9909-c35727e93a68
DOI: 10.21203/rs.3.rs-860700/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Primary Nasal Epithelial Cells As a Type-II Alveolar Surrogate Cell Culture Model for ABCA-3 DeficiencyDOI 10.21203/rs.3.rs-860700/v1Read

Characterization of Commercially Available Human Primary Alveolar Epithelial CellsSemantic proximity Read

Functional Characterization of ATP-Binding Cassette Transporter A3 Mutations from Infants with Respiratory Distress Syndrome.Semantic proximity Read

Lentiviral-mediated gene complementation rescues pathogenic <i>ABCA3</i> variantsSemantic proximity Read

Respiratory syncytial virus potentiates ABCA3 mutation-induced loss of lung epithelial cell differentiation.Semantic proximity Read

Assessment of cell line models of primary human cells by Raman spectral phenotyping.Semantic proximity Read

Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome.Semantic proximity Read

Functional Genomics of ABCA3 VariantsSemantic proximity Read

Some ABCA3 mutations elevate ER stress and initiate apoptosis of lung epithelial cells.Semantic proximity Read

ABCA3 missense mutations causing surfactant dysfunction disorders have distinct cellular phenotypes.Semantic proximity Read

Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype.Semantic proximity Read

Comparative primary paediatric nasal epithelial cell culture differentiation and RSV-induced cytopathogenesis following culture in two commercial mediaSemantic proximity Read

Human ABCA3, a product of a responsible gene for abca3 for fatal surfactant deficiency in newborns, exhibits unique ATP hydrolysis activity and generates intracellular multilamellar vesicles.Semantic proximity Read