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Article

Respiratory syncytial virus potentiates ABCA3 mutation-induced loss of lung epithelial cell differentiation.

Human molecular genetics - 15 Jun 2012

Kaltenborn Eva, Kern Suncana, Frixel Sabrina, Fragnet Laetitia, Conzelmann Karl-Klaus, Zarbock Ralf, Griese Matthias

Abstract excerpt

ATP-binding cassette transporter A3 (ABCA3) is a lipid transporter active in lung alveolar epithelial type II cells (ATII) and is essential for their function as surfactant-producing cells. ABCA3 mutational defects cause respiratory distress in newborns and interstitial lung disease (ILD) in children. The molecular pathomechanisms are largely unknown; however, viral infections may initiate or aggravate ILDs....

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Source

Identifiers

PMID: 22434821
DOI: 10.1093/hmg/dds107

Genes

ABCA3
SNAI1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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