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Article

Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome.

The Journal of biological chemistry - 7 Apr 2006

Cheong Naeun, Madesh Muniswamy, Gonzales Linda W, Zhao Ming, Yu Kevin, Ballard Philip L, Shuman Henry

Abstract excerpt

Members of the ATP binding cassette (ABC) protein superfamily actively transport a wide range of substrates across cell and intracellular membranes. Mutations in ABCA3, a member of the ABCA subfamily with unknown function, lead to fatal respiratory distress syndrome (RDS) in the newborn. Using cultured human lung cells, we found that recombinant wild-type hABCA3 localized to membranes of both lysosomes and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16415354
DOI: 10.1074/jbc.M507515200

Genes

ABCA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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