Article

Repression of miR-764-5p by enhancing IGF1R and cochaperone CHIP expression in mesenchymal stem cells (MSCs) regulates cardioprotective effects in Aging-Spontaneously Hypertensive rats model

2023-11-29

Abstract excerpt

Age-associated cardiovascular disease (CVD) progression is marked by increased misfolded proteins and reduced growth factor receptor activity. Evidence links the co-chaperone CHIP and insulin-like growth factor-1 receptor (IGF1R) to stem cell dynamics and function through miR-764-5p in rat adipose-derived stem cells (rADSCs) remains largely unknown. We observed that short-term hypoxia (6 h) downregulated miR-764-5...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b7c685e-0927-51e5-8471-48ec4bc147d8
DOI: 10.21203/rs.3.rs-3605059/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repression of miR-764-5p by enhancing IGF1R and cochaperone CHIP expression in mesenchymal stem cells (MSCs) regulates cardioprotective effects in Aging-Spontaneously Hypertensive rats modelDOI 10.21203/rs.3.rs-3605059/v1Read

Cardiovascular disease risk factors induce mesenchymal features and senescence in cardiac endothelial cellsSemantic proximity Read

Bioinformatics Network Analyses of Growth Differentiation Factor 11 Anti-aging StudySemantic proximity Read

Investigating the function of the non-coding RNAs miR-27b and Herna1 in pathologic cardiac hypertrophySemantic proximity Read

The whole profiling and competing endogenous RNA network analyses of noncoding RNAs in adipose-derived stem cells from diabetic, old, and young patientsSemantic proximity Read

Super-Enhancer-Driven LncRNA UNC5B-AS1 Inhibits Inflammatory Phenotypic Transition in Pulmonary Artery Smooth Muscle Cells via Lactylation.Semantic proximity Read

Glucocorticoid chrono-pharmacology unveils novel targets for the cardiomyocyte-specific GR-KLF15 axis in cardiac glucose metabolismSemantic proximity Read

Identification of Heat shock protein family A member 5 (HSPA5) targets involved in nonalcoholic fatty liver diseaseSemantic proximity Read

Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stressSemantic proximity Read

Sirtuin 7 ameliorates cuproptosis, myocardial remodeling and heart dysfunction in hypertension through the modulation of YAP/ATP7A signalingSemantic proximity Read

The aging-induced long non-coding RNA <i>MIRIAL</i> controls endothelial cell and mitochondrial functionSemantic proximity Read

ROS‐ and HIF1α‐dependent IGFBP3 upregulation blocks IGF1 survival signaling and thereby mediates high‐glucose‐induced cardiomyocyte apoptosisSemantic proximity Read

Cardiomyocyte-specific expression of HIF-1α mediates the cardioprotective effects of Growth Hormone Releasing Hormone (GHRH)Semantic proximity Read