Article

Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy

2022-12-14

Abstract excerpt

Digestive Chagas disease (DCD) is an enteric neuropathy caused by Trypanosoma cruzi infection. There is a lack of evidence on the mechanism of pathogenesis and rationales for treatment. We used a mouse model that recapitulates key clinical manifestations to study how infection dynamics shape DCD pathology, and the impact of treatment with the front-line drug benznidazole. Curative treatment at 6 weeks post-infect...

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Literature Corpus work: 4b429bc1-ee28-566a-8be5-ec8eca1f2981
DOI: 10.1101/2022.12.14.520395

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Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapyDOI 10.1101/2022.12.14.520395Read

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