Back to search

Article

Hydroxytyrosol Attenuates Hippocampal Inflammation and Damage in an Experimental Model ofParkinson’s Disease: The Critical Role of the JNK–c-Jun–AP-1 Signaling Pathway in Neuroprotection

2026-07-09

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is a common neurodegenerative disorder marked by the loss of dopaminergic neurons in the substantia nigra, resulting in motor and non-motor symptoms. Inflammation caused by microglia in the hippocampus and overactivation of the JNK–c-Jun–AP-1 signaling pathway are key mechanisms involved in cognitive deficits associated with PD. This study examined the anti-infl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4b0e551b-6656-54fe-ae0b-036654f538b6
DOI
10.21203/rs.3.rs-10165236/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Hydroxytyrosol Attenuates Hippocampal Inflammation and Damage in an Experimental Model ofParkinson’s Disease: The Critical Role of the JNK–c-Jun–AP-1 Signaling Pathway in NeuroprotectionDOI 10.21203/rs.3.rs-10165236/v1
Microglial Activation Contributes to Cognitive Impairments in Rotenone-induced Mouse Parkinson’s Disease ModelSemantic proximity
Pathogenesis of Parkinson’s disease: oxidative stress, environmental impact factors and inflammatory processesSemantic proximity
Ellagic acid produces neuroprotection against LPS-induced dopamine neurotoxicity via the inhibition of microglial NLRP3 inflammasome activationSemantic proximity
Ellagic acid produces neuroprotection against LPS-induced dopamine neurotoxicity via the inhibition of microglial NLRP3 inflammasome activationSemantic proximity
Ellagic acid produces neuroprotection against LPS-induced dopamine neurotoxicity via the inhibition of microglial NLRP3 inflammasome activationSemantic proximity
Pharmacological Blocker of NF-κb and Mitochondrial Ros Restrict NLRP3&nbsp;Inflammasome Activation and Rescue Dopaminergic Neurons in Vitro and in Vivo Parkinson’s DiseaseSemantic proximity
Camptothecin regulates microglia polarization and exerts neuroprotective effects via the AKT/Nrf2/HO-1-NF-κB signal axis in vivo and in vitroSemantic proximity
Camptothecin regulates microglia polarization and exerts neuroprotective effects via the AKT/Nrf2/HO-1-NF-κB signal axis in vivo and in vitroSemantic proximity
Programmed Death-1 Deficiency Aggravates Motor Dysfunction In MPTP Model of Parkinson's Disease By Inducing Microglial Activation And Neuroinflammation In MiceSemantic proximity
ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats.Semantic proximity
Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: Relevance to oxidative stress and neuroinflammation in Parkinson's diseaseSemantic proximity
Combined neuroprotective potential of Levodopa and Resveratrol to ameliorates cognitive impairments in rotenone-induced Parkinson's disease via targeting TLR mediated neuroinflammationSemantic proximity
Select a neighboring publication to make it the new centre.