Article

Haplotype-aware sequence alignment to pangenome graphs

2023-11-17

Abstract excerpt

Modern pangenome graphs are built using haplotype-resolved genome assemblies. During read mapping to a pangenome graph, prioritizing alignments that are consistent with the known haplotypes has been shown to improve genotyping accuracy. However, the existing rigorous formulations for sequence-to-graph co-linear chaining and alignment problems do not consider the haplotype paths in a pangenome graph. This often lea...

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Literature Corpus work: 4b039649-d172-53a3-989b-039624099ef1
DOI: 10.1101/2023.11.15.566493

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