Pangenome graph construction from genome alignments with Minigraph-Cactus.

Abstract excerpt

Pangenome references address biases of reference genomes by storing a representative set of diverse haplotypes and their alignment, usually as a graph. Alternate alleles determined by variant callers can be used to construct pangenome graphs, but advances in long-read sequencing are leading to widely available, high-quality phased assemblies. Constructing a pangenome graph directly from assemblies, as opposed to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Drosophila melanogaster