Rapid, accurate long- and short-read mapping to large pangenome graphs with vg Giraffe

Abstract excerpt

1 We previously introduced Giraffe, a short-read-to-pangenome graph mapper available in the vg pangenomics toolkit. Giraffe was fast and accurate for mapping short reads to human-scale pangenomes, but struggled with long reads. Long reads present a unique challenge to pangenome mapping algorithms due to their length and error profile, which allow them to take more topologically complex paths through the pangenome...

Topics

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• Algorithms
• Computational Biology
• Genome, Fungal
• Genome, Human
• Genotyping Techniques
• High-Throughput Nucleotide Sequencing
• Quantitative Trait Loci
• Saccharomyces

Identifiers and source

Literature Corpus work

036cdbe1-6454-5174-9090-47170f0e71f3

DOI

10.1101/2025.09.29.678807