Article

Rewiring capsule production by CRISPRi-based genetic oscillators demonstrates a functional role of phenotypic variation in pneumococcal-host interactions

2023-06-03

Abstract excerpt

Phenotypic variation is the phenomenon in which clonal cells display different traits even under identical environmental conditions. This plasticity is thought to be important for processes including bacterial virulence 1–8 , but direct evidence for its relevance is often lacking. For instance, variation in capsule production in the human pathogen Streptococcus pneumoniae has been linked to different clinical ou...

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Literature Corpus work: 4af327cc-11eb-50ad-91ad-97e396c72a8e
DOI: 10.1101/2023.06.03.543575

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