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Article

ADAM15 regulates endothelial permeability and neutrophil migration via Src/ERK1/2 signalling.

Cardiovascular research - 15 Jul 2010

Sun Chongxiu, Wu Mack H, Guo Mingzhang, Day Mark L, Lee Eugene S, Yuan Sarah Y

Abstract excerpt

AIMS: Endothelial barrier dysfunction is a key event in the pathogenesis of vascular diseases associated with inflammation. ADAM (a disintegrin and metalloprotease) 15 has been shown to contribute to the development of vascular inflammation. However, its role in regulating endothelial barrier function is unknown. The aim of this study was to examine the effect of ADAM15 on endothelial permeability and its...

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Source

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Identifiers

PMID: 20189953
DOI: 10.1093/cvr/cvq060
PMCID: PMC2895539

Genes

ADAM15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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