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Article

CLDN6 promotes chemoresistance through GSTP1 in human breast cancer

7 Nov 2017

Abstract excerpt

BACKGROUND: Claudin-6 (CLDN6), a member of CLDN family and a key component of tight junction, has been reported to function as a tumor suppressor in breast cancer. However, whether CLDN6 plays any role in breast cancer chemoresistance remains unclear. In this study, we investigated the role of CLDN6 in the acquisition of chemoresistance in breast cancer cells. METHODS: We manipulated the expression of CLDN6 in...

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PMID: 29116019
DOI: 10.1186/s13046-017-0627-9

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