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Article

Targeting claudin‐4 enhances chemosensitivity in breast cancer

22 Feb 2020

Abstract excerpt

Triple negative breast cancer (TNBC) is characterized by highly aggressive phenotype, limited treatment options and a poor prognosis. In the present study, we examined the therapeutic effect of anti-claudin (CLDN)-4 extracellular domain antibody, 4D3, on TNBC. When the expression of CLDN4 and CLDN1 in invasive ductal carcinoma (IDC) was examined in 114 IDC (78 cases from 2004 to 2009 in a single center and 36...

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PMID: 32086991
DOI: 10.1111/cas.14361

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