Article
A map of human cancer signaling.
Molecular systems biology - 1 Jan 2007
Cui Qinghua, Ma Yun, Jaramillo Maria, Bari Hamza, Awan Arif, Yang Song, Zhang Simo, Liu Lixue, Lu Meng, O'Connor-McCourt Maureen, Purisima Enrico O, Wang Edwin
Abstract excerpt
We conducted a comprehensive analysis of a manually curated human signaling network containing 1634 nodes and 5089 signaling regulatory relations by integrating cancer-associated genetically and epigenetically altered genes. We find that cancer mutated genes are enriched in positive signaling regulatory loops, whereas the cancer-associated methylated genes are enriched in negative signaling regulatory loops. We...
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