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Lipid mediated inhibition of Niemann-Pick C1 protein is an evolutionary conserved feature of multiple <i>Mycobacterium</i> lineages and non-tubercular mycobacteria

2021-09-06

Abstract excerpt

Mycobacterium tuberculosis ( Mtb) is the causative agent of tuberculosis (TB) and is a major cause of human morbidity and mortality. Crucially, Mtb can persist and replicate within host macrophages (MФ) and subvert multiple antimicrobial defense mechanisms. How this is achieved is incompletely understood. Previously, we reported that lipids shed by persistent mycobacteria inhibit NPC1, the lysosomal protein defi...

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Literature Corpus work
4a8eeda8-5bdc-58aa-a336-d366e86d55c9
DOI
10.1101/2021.09.06.459187
Open publication

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Lipid mediated inhibition of Niemann-Pick C1 protein is an evolutionary conserved feature of multiple <i>Mycobacterium</i> lineages and non-tubercular mycobacteriaDOI 10.1101/2021.09.06.459187
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