Article

Astroglial dysfunctions drive aberrant synaptogenesis in developing brain with lengthy general anesthesia

2018-11-22

Abstract excerpt

Lengthy use of general anesthetics (GAs) causes cognitive deficits in developing brain, which has raised significant clinical concerns such that FDA is warning on the use of GAs in children younger than 3 years. However, the molecular and cellular mechanisms for GAs-induced neurotoxicity remain largely unknown. Here we report that sevoflurane, a commonly used GA in pediatrics, causes compromised astrocyte morphoge...

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Literature Corpus work: 19671012-1180-5f38-8f12-80ded88dd035
DOI: 10.1101/477075

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