Article

AAV-mediated age- and circuit-dependent restoration of photoreceptor synaptic structure and function in α2δ4-associated retinal synaptopathy

2026-07-25

Abstract excerpt

<h4>Purpose</h4> Synaptic dysfunction and neurite remodeling are early features of many inherited retinal diseases, but whether synaptic function can be restored after circuit remodeling remains unclear. We evaluated the therapeutic potential of adeno-associated virus (AAV)-mediated α2δ4 gene supplementation in a mouse model of CACNA2D4 -associated retinal synaptopathy. <h4>Methods</h4> AAV8-GRK1-α2δ4 was deli...

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Literature Corpus work: 6916cbcb-fd3f-59fc-94f6-c36671a83f56
DOI: 10.64898/2026.07.21.739956

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