Article

Identification of a genomic DNA sequence that quantitatively modulates KLF1 expression in differentiating human hematopoietic cells

2021-11-22

Abstract excerpt

Expression of the β-like globin genes is under strict developmental control, with both direct and indirect inputs responsible for this effect. One of the major players regulating their transition is KLF1/EKLF, where even a two-fold difference in its level alters the regulation of globin switching. We have reproduced this change in KLF1 expression in both cell lines and primary human cells, thus demonstrating that...

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Literature Corpus work: 4a5199ee-081c-5def-8663-f0769fc2b9e3
DOI: 10.1101/2021.11.22.469597

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