Article

Occurrence of variants of unknown clinical significance in genetic testing for hereditary breast and ovarian cancer syndrome and Lynch syndrome - A Literature review and analytical observational retrospective cohort study

2022-09-27

Abstract excerpt

<h4>Background: </h4> and purpose Over the last decade, the implementation of multigene panels for hereditary tumor syndrome has increased at our institution (Inselspital, University Hospital Berne, Switzerland). The aim of this study was to determine the prevalence of variants of unknown significance (VUS) in patients with suspected Lynch syndrome (LS) and suspected hereditary breast and ovarian cancer syndrome,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4a0ac31e-6405-55d6-bd4e-ccfa6c7b0548
DOI: 10.21203/rs.3.rs-1893202/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Occurrence of variants of unknown clinical significance in genetic testing for hereditary breast and ovarian cancer syndrome and Lynch syndrome - A Literature review and analytical observational retrospective cohort studyDOI 10.21203/rs.3.rs-1893202/v1Read

Occurrence of variants of unknown clinical significance in genetic testing for hereditary breast and ovarian cancer syndrome and Lynch syndrome: a literature review and analytical observational retrospective cohort study.Semantic proximity Read

Uncommon variants detected via hereditary cancer panel and suggestions for genetic counseling.Semantic proximity Read

UMD-MLH1/MSH2/MSH6 databases: description and analysis of genetic variations in French Lynch syndrome families.Semantic proximity Read

Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.Semantic proximity Read

Gene variants of unknown clinical significance in Lynch syndrome. An introduction for clinicians.Semantic proximity Read

Increased Co-Occurrence of Pathogenic Variants in Hereditary Breast and Ovarian Cancer and Lynch Syndromes: A Consequence of Multigene Panel Genetic Testing?Semantic proximity Read

Initial Results of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer and Lynch Syndrome.Semantic proximity Read

Multigene Panel Testing Provides a New Perspective on Lynch Syndrome.Semantic proximity Read

Evaluating the effect of unclassified variants identified in MMR genes using phenotypic features, bioinformatics prediction, and RNA assays.Semantic proximity Read

Use of multigene-panel identifies pathogenic variants in several CRC-predisposing genes in patients previously tested for Lynch Syndrome.Semantic proximity Read

Lynch Syndrome Germline Mutations in Breast Cancer: Next Generation Sequencing Case-Control Study of 1,263 ParticipantsSemantic proximity Read

Integrated analysis of unclassified variants in mismatch repair genes.Semantic proximity Read