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Article

UMD-MLH1/MSH2/MSH6 databases: description and analysis of genetic variations in French Lynch syndrome families.

Database : the journal of biological databases and curation - 1 Jan 2013

Grandval Philippe, Fabre Aurélie J, Gaildrat Pascaline, Baert-Desurmont Stéphanie, Buisine Marie-Pierre, Ferrari Anthony, Wang Qing, Béroud Christophe, Olschwang Sylviane

Abstract excerpt

Lynch syndrome is an autosomal dominant disease caused by germ line heterozygous mutations mainly involving the MSH2, MLH1 and MSH6 genes that belong to the DNA MisMatch Repair (MMR) genes family. The French network counting the 16 licensed laboratories involved in Lynch syndrome genetic testing developed three locus-specific databases with the UMD software (www.umd.be/MLH1/, www.umd.be/MSH2/ and...

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Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23729658
DOI: 10.1093/database/bat036
PMCID: PMC3668602

Genes

MLH1
MSH2
MSH6

Provenance

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