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Article

Use of multigene-panel identifies pathogenic variants in several CRC-predisposing genes in patients previously tested for Lynch Syndrome.

Clinical genetics - 1 Oct 2017

Hansen Maren F, Johansen Jostein, Sylvander Anna E, Bjørnevoll Inga, Talseth-Palmer Bente A, Lavik Liss A S, Xavier Alexandre, Engebretsen Lars F, Scott Rodney J, Drabløs Finn, Sjursen Wenche

Abstract excerpt

BACKGROUND: Many families with a high burden of colorectal cancer fulfil the clinical criteria for Lynch Syndrome. However, in about half of these families, no germline mutation in the mismatch repair genes known to be associated with this disease can be identified. The aim of this study was to find the genetic cause for the increased colorectal cancer risk in these unsolved cases. MATERIALS AND METHODS: To reach...

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Identifiers

PMID: 28195393
DOI: 10.1111/cge.12994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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