Article

A Computationally De-Risked CD47 Inhibitor for Glioblastoma

2026-08-31

Abstract excerpt

<title>Abstract</title> <p> Background Glioblastoma (GBM) is a lethal primary brain tumor that leverages the CD47-SIRPα "don't eat me" signal to evade the innate immune system. First-generation antibody therapies targeting this pathway have failed due to significant hematological toxicity and limited efficacy, creating an urgent need for safer, more effective therapeutic modalities. Methods I employed a "compu...

Identifiers and source

Literature Corpus work: 49fde194-a444-5f9f-8fdb-007ce9ba35ad
DOI: 10.21203/rs.3.rs-10854402/v1

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