Article

Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein

2023-07-19

Abstract excerpt

The use of VHHs (Variable domain of the Heavy-chain of the Heavy-chain-only antibodies) as disease-modifying biomolecules in neurodegenerative disorders holds promises including to target aggregation-sensitive proteins. Exploitation of their clinical values dependents however on the capacity to deliver VHHs with optimal physico-chemical properties for their specific context of use. We described previously a VHH wi...

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Literature Corpus work: 49f7cf00-4ed6-5e02-9e6f-3497e8433b21
DOI: 10.1101/2023.07.18.549252

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