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Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

2 Sept 2022

Abstract excerpt

Huntington disease (HD) is a neurodegenerative disease associated with polyglutamine expansion in the protein huntingtin (HTT). Although the length of the polyglutamine repeat correlates with age at disease onset and severity, psychological, cognitive and behavioral complications point to the existence of disease modifiers. Mitochondrial dysfunction and metabolic deregulation are both associated with the HD but,...

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PMID: 36052548
DOI: 10.1242/dmm.049492

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