Article

A practical framework RNMF for the potential mechanism of cancer progression with the analysis of genes cumulative contribution abundance

2021-08-13

Abstract excerpt

Mutational signatures can reveal the mechanism of tumorigenesis. We developed the RNMF software for mutational signatures analysis, including a key model of cumulative contribution abundance (CCA) which was designed to highlight the association between genes and mutational signatures. Applied it to 1073 esophageal squamous cell carcinoma (ESCC) and found that APOBEC signatures (SBS2* and SBS13*) mediated the occu...

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Literature Corpus work: 49ba85cd-a986-573f-b2d3-ef151f740289
DOI: 10.1101/2021.08.12.456096

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