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DNA Damage Response Alterations and Immune Checkpoint Blockade Outcomes Across Multiple Cancers.

JCO precision oncology - 1 Jun 2026

Ma Tian-Chi, Guo Wen-Heng, Liu De-Min, Li Qian-Jie, Wang Ren-Ci, Wang He-Rong, Li Juan, He Ya-Long, Yin An-An, Lin Wei

Abstract excerpt

PURPOSE: DNA damage response (DDR) alterations have been implicated in immunotherapy efficacy, but their pan-cancer predictive value for immune checkpoint blockade (ICB) remains unclear. We aimed to characterize DDR mutational landscapes and evaluate their ability to predict ICB outcomes across multiple cancer types. MATERIALS AND METHODS: We integrated multiomics data from The Cancer Genome Atlas with...

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PMID: 42372205
DOI: 10.1200/PO-25-00810

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