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Nicotine exacerbates intervertebral disc degeneration via NF-κB/MAPK-dependent inflammatory activation and cellular senescence

2025-05-21

Abstract excerpt

<title>Abstract</title> <p>Cigarette smoking constitutes a major modifiable risk factor for intervertebral disc degeneration (IVDD), yet the mechanistic underpinnings remain incompletely elucidated. This study aimed to elucidate the pathological effects of nicotine-the primary addictive component in tobacco-on IVDD, focusing on its role in inflammation, extracellular matrix (ECM) disruption, and cellular senescen...

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Literature Corpus work
497086f5-9b01-5666-945b-86b0d225a28c
DOI
10.21203/rs.3.rs-6586785/v1
Open publication

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Nicotine exacerbates intervertebral disc degeneration via NF-κB/MAPK-dependent inflammatory activation and cellular senescenceDOI 10.21203/rs.3.rs-6586785/v1
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