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Article

Effect of Nicotine on Spinal Disc Cells: A Cellular Mechanism for Disc Degeneration

24 Feb 2004

Abstract excerpt

STUDY DESIGN: Experimental investigation to determine the effect of nicotine on intervertebral spinal disc nucleus pulposus (NP) cells cultured in vitro. OBJECTIVES.: To evaluate the effects of nicotine on cell proliferation, extracellular matrix production, and viability of NP cells in three-dimensional alginate constructs cultured in vitro. SUMMARY OF BACKGROUND DATA: Numerous studies confirm that smoking is a...

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PMID: 15129075
DOI: 10.1097/01.brs.0000101422.36419.d8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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