Article

Tau Aggregation is Altered by Variations in its Projection Domain

2024-11-25

Abstract excerpt

The intrinsically disordered microtubule-associated protein tau is known for its aberrant aggregation into neurofibrillary tangles as found in neuropathologies such as Alzheimer’s disease. This study compares three N-terminal isoforms of mutant R5L and of wild type tau to investigate how this mutation and the length of the projection domain affects aggregation behavior. Tau polymers in vitro were examined using a...

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Literature Corpus work: 494da675-dd95-5ad8-a864-282422df395c
DOI: 10.1101/2024.11.22.624898

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