Article

Critical assessment of intratumor and low-biomass microbiome using long-read sequencing

2026-02-04

Abstract excerpt

The detection of low-biomass microbial DNA in human tissues is often confounded by contamination, as demonstrated in the debates over the existence of microbiomes in the placenta, brain, blood, and tumors. Here we show that genomic DNA fragment length serves as a discriminator: while genuine microbiome genomes have long genomic DNA fragments, contaminant DNA is typically short. Using germ-free mouse tissues with b...

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Literature Corpus work: 48d2c2e6-0415-50ac-a1f9-e7f4175465ab
DOI: 10.64898/2026.02.02.703393

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