Article

Application of an ecology-based analytic approach to discriminate signal and noise in low-biomass microbiome studies: whole lung tissue is the preferred sampling method for amplicon-based characterization of murine lung microbiota

2020-09-08

Abstract excerpt

<h4>Background</h4> Low-biomass microbiome studies (such as those of the lungs, placenta, and skin) are vulnerable to contamination and sequencing stochasticity, which obscure legitimate microbial signal. Since low-biomass microbiome fields have had variable success in establishing the reality and clinical significance of identified microbiota, we sought to develop and apply an analytical approach to discriminate...

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Literature Corpus work: 6b5312b2-d890-5dc1-b678-46d22ee72b72
DOI: 10.1101/2020.09.08.283259

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