Article

CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

2024-03-01

Abstract excerpt

Chimeric antigen receptor (CAR)-engineered T and NK cells can cause durable remission of B-cell malignancies; however, limited persistence restrains the full potential of these therapies in many patients. The FAS ligand (FAS-L)/FAS pathway governs naturally-occurring lymphocyte homeostasis, yet knowledge of which cells express FAS-L in patients and whether these sources compromise CAR persistence remains incomplet...

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Literature Corpus work: 48d0caaa-e602-51e9-b798-cb445fc93efc
DOI: 10.1101/2024.02.26.582108

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