Article

Modified comb-shaped antisense oligonucleotides may secure us against many important viral diseases including AIDS

2021-12-29

Abstract excerpt

To inhibit HIV replication and infection, we have designed novel linear single stranded modified antisense nucleic acid oligonucleotides ending with or without chain terminating bases (Which resemble the shape of the comb). They were targeting specifically the HIV-1 clone pNL4-3 strong promoter pre PBS region to stop cDNA synthesis within or before the R region, preventing the viral reverse transcriptase (RT) jump...

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Literature Corpus work: 48b6772b-d1e8-53e3-a57a-dd6f0df7c51e
DOI: 10.21203/rs.3.rs-1207172/v1

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