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Article

Small molecules targeting viral <scp>RNA</scp>

16 Jun 2016

Abstract excerpt

Highly conserved noncoding RNA (ncRNA) elements in viral genomes and transcripts offer new opportunities to expand the repertoire of drug targets for the development of antiinfective therapy. Ligands binding to ncRNA architectures are able to affect interactions, structural stability or conformational changes and thereby block processes essential for viral replication. Proof of concept for targeting functional...

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PMID: 27307213
DOI: 10.1002/wrna.1373

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