Article

Microbiota-dependent indole production is required for the development of collagen-induced arthritis

2023-10-13

Abstract excerpt

Altered tryptophan catabolism has been identified in inflammatory diseases like rheumatoid arthritis (RA) and spondyloarthritis (SpA), but the causal mechanisms linking tryptophan metabolites to disease are unknown. Using the collagen-induced arthritis (CIA) model we identify alterations in tryptophan metabolism, and specifically indole, that correlate with disease. We demonstrate that both bacteria and dietary tr...

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Literature Corpus work: 48690f4c-f19a-5f3b-909c-51db1a06332f
DOI: 10.1101/2023.10.13.561693

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