Article

Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes

2024-06-12

Abstract excerpt

EPAS1 HIF2α is the primary gene implicated in systemic hypoxia adaptation. Conversely, aberrantly activated EPAS1 HIF2α acts as a tumor driver against which anti-tumor therapeutics are proven effective. We elucidated connections between adaptation to systemic hypoxia in high-altitude populations, such as Tibetans and Sherpas, and human tumors. Similar to the accelerated adaptability observed in high-altitude popu...

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Literature Corpus work: 48676bb6-485f-5c06-b49b-dfdb9e3daa9f
DOI: 10.1101/2024.06.10.594693

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