Article
COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype.
Immunologic research - 1 Mar 2013
Packard Thomas A, Li Quan Z, Cosgrove Gregory P, Bowler Russell P, Cambier John C
Abstract excerpt
The role of autoimmune pathology in development and progression of chronic obstructive pulmonary disease (COPD) is becoming increasingly appreciated. In this study, we identified serum autoantibody reactivities associated with chronic bronchitis or emphysema, as well as systemic autoimmunity and associated lung disease. Using autoantigen array analysis, we demonstrated that COPD patients produce autoantibodies...
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