Article

Pazopanib induces dramatic but transient contraction of myeloid suppression compartment in favor of adaptive immunity

2020-05-01

Abstract excerpt

Anti-angiogenic tyrosine-kinase inhibitors (TKIs) and immune checkpoint blockade (ICB) constitute the backbone of metastatic renal cell carcinoma (mRCC) treatment. The development of the optimal combinatorial or sequential approach is hindered by the lack of comprehensive data regarding TKI-induced immunomodulation and its kinetics. Through the use of orthogonal transcriptomic and phenotyping platforms combined wi...

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Literature Corpus work: 48598d68-4b1f-5cb6-8d9e-12b9d7cdf52a
DOI: 10.1101/2020.05.01.071613

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