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Article

Extracellular vesicles of stromal origin target and support hematopoietic stem and progenitor cells.

The Journal of cell biology - 3 Jul 2017

Stik Gregoire, Crequit Simon, Petit Laurence, Durant Jennifer, Charbord Pierre, Jaffredo Thierry, Durand Charles

Abstract excerpt

Extracellular vesicles (EVs) have been recently reported as crucial mediators in cell-to-cell communication in development and disease. In this study, we investigate whether mesenchymal stromal cells that constitute a supportive microenvironment for hematopoietic stem and progenitor cells (HSPCs) released EVs that could affect the gene expression and function of HSPCs. By taking advantage of two fetal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28630143
DOI: 10.1083/jcb.201601109
PMCID: PMC5496607

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