Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease.

doi:10.1186/s13046-020-01776-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease.

Journal of experimental & clinical cancer research : CR - 1 Feb 2021

Forte Dorian, Barone Martina, Morsiani Cristina, Simonetti Giorgia, Fabbri Francesco, Bruno Samantha, Bandini Erika, Sollazzo Daria, Collura Salvatore, Deregibus Maria Chiara, Auteri Giuseppe, Ottaviani Emanuela, Vianelli Nicola, Camussi Giovanni, Franceschi Claudio, Capri Miriam, Palandri Francesca, Cavo Michele, Catani Lucia

Abstract excerpt

BACKGROUND: Myelofibrosis (MF) is a clonal disorder of hemopoietic stem/progenitor cells (HSPCs) with high prevalence in elderly patients and mutations in three driver genes (JAK2, MPL, or CALR). Around 10-15% of patients are triple-negative (TN) for the three driver mutations and display significantly worse survival. Circulating extracellular vesicles (EVs) play a role in intercellular signaling and are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD34

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Vesicles

Share to Hematopoietic Stem Cells

Share to Immunophenotyping

Share to Inflammation

Share to Inflammation Mediators

Share to Janus Kinase 2

Share to Primary Myelofibrosis

Source

Open in PubMed Open full text

Identifiers

PMID: 33522952
DOI: 10.1186/s13046-020-01776-8
PMCID: PMC7849077

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease.PMID 33522952Read ↗

Early and late stage MPN patients show distinct gene expression profiles in CD34+ cellsSemantic proximity Read ↗

Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor CellsSemantic proximity Read ↗

Contributions of bone marrow monocytes/macrophages in myeloproliferative neoplasms with JAK2V617F mutation.Semantic proximity Read ↗

Extracellular vesicles in acute myeloid leukemia: The role in disease pathogenesis, potential biomarker, and application in clinical settingsSemantic proximity Read ↗

Revisiting Circulating Extracellular Matrix Fragments as Disease Markers in Myelofibrosis and Related NeoplasmsSemantic proximity Read ↗

Red blood cell extracellular vesicles: new frontiers in hematological biomarker discoverySemantic proximity Read ↗

Altered Expression of microRNAs Implicated in Hematopoietic Dysfunction in the Extracellular Vesicles of Bone Marrow-Mesenchymal Stromal Cells in Aplastic AnemiaSemantic proximity Read ↗

Microvesicles from Mesenchymal Stromal Cells Are Involved in HPC-Microenvironment Crosstalk in Myelodysplastic PatientsSemantic proximity Read ↗

JAK2V617F-Positive Endothelial Cells Induce Apoptosis and Release JAK2V617F-Positive MicroparticlesSemantic proximity Read ↗

Exosomes as a promising tool for research and molecular diagnostics of myeloproliferative disordersSemantic proximity Read ↗

Thrombo-inflammatory endothelial signatures in <i>JAK2</i> -mutated myeloproliferative neoplasmsSemantic proximity Read ↗

Platelet proteo-transcriptomic profiling validates mediators of thrombosis and proteostasis in patients with myeloproliferative neoplasmsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.