Article

Transcriptomic Profiling of Thyroid Eye Disease Orbital Fibroblasts Identifies Sorafenib as a Novel Therapeutic

2026-04-24

Abstract excerpt

Thyroid eye disease (TED) is a debilitating condition characterized by orbital fibroblast (OF) activation and excessive hyaluronic acid (HA) accumulation within the retro-ocular space. While IGF-1R blockade with teprotumumab has significantly advanced TED management, incomplete clinical responses and disease relapse underscore the need to identify alternative targets. In this study, we used high-throughput RNA seq...

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Literature Corpus work: 481b9908-398c-53ff-91b8-acd7e867eff0
DOI: 10.64898/2026.04.21.719973

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