Article

Estimating the Probability of Early Afterdepolarization and Predicting Arrhythmic Risk associated with Long QT Syndrome Type 1 Mutations

2020-04-10

Abstract excerpt

Early after-depolarizations (EADs) are action potential (AP) repolarization abnormalities that can trigger lethal arrhythmias. Simulations using biophysically-detailed cardiac myocyte models can reveal how model parameters influence the probability of these cellular arrhythmias, however such analyses can pose a huge computational burden. We have previously developed a highly simplified approach in which logistic r...

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Literature Corpus work: 47f460f9-9a5b-5865-ace8-34fc39de2a08
DOI: 10.1101/2020.04.09.034843

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