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Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies

8 Mar 2024

Abstract excerpt

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate tumor suppressor mechanism and participates in the biological processes of tumors. Intriguingly, mesenchymal and dedifferentiated cancer cells, which are usually resistant to apoptosis and traditional therapies, are exquisitely vulnerable...

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PMID: 38453898
DOI: 10.1038/s41392-024-01769-5

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